| Pair Name | Eugenol, 2-methoxyestradiol | ||
| Phytochemical Name | Eugenol (PubChem CID: 3314 ) | ||
| Anticancer drug Name | 2-methoxyestradiol (PubChem CID: 66414 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | Eugenol, 2-methoxyestradiol | |||
| Disease Info | [ICD-11: 2C82.0] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 | |
| Result | Combining these agents may allow ameliorating any adverse effects of either 2-ME(2) or eugenol alone by reducing their individual concentrations should these two agents be developed for human use. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):25-35. doi: 10.1016/j.jsbmb.2008.11.002. | Click |
